The goal of external beam radiotherapy is to provide precise dose localisation in the treatment volume of the target with minimal damage to the surrounding normal tissues. Ion beams such as protons and carbon ions provide excellent dose distributions due primarily to their finite range allowing a significant reduction of undesired exposure to normal tissues. Careful treatment planning is required for the given type and localisation of the tumour to be treated in order to maximise the treatment efficiency and minimise the dose to the normal tissues. Radiation exposure in the out-of-field volumes arises from secondary neutrons and photons particle fragments and photons from activated materials. These unavoidable doses should be considered from the standpoint of radiological protection of the patient. Radiological protection of medical staff at ion beam therapy facilities requires special attention. Appropriate management and control are required for the therapy equipment and also for the air in the treatment room which can be activated by the particle beam and its secondaries. Radiological protection and safety management should always be in conformity with regulatory requirements. The current regulations for occupational exposures in photon radiotherapy are applicable to ion beam radiotherapy with protons or carbon ions. Ion beam radiotherapy requires however a more complex treatment system than conventional radiotherapy and appropriate training of the staff and suitable quality assurance programme are recommended to avoid possible accidental exposure to the patient to minimise unnecessary doses to normal tissues and to minimise radiation exposure of staff. Language: English